NAD+ 500mg & 1000mg

NAD+ is potent and rate-dependent — all administrations must be doctor-prescribed, pharmacy-compounded, and clinician-administered under strict governance and TGA compliance.

Product Information

Drug: Nicotinamide Adenine Dinucleotide (oxidised form)

Concentration: 100 mg/mL

Vial size: 5 mL (total = 500 mg NAD+ or 10ml - 1000mg NAD+)

Route: IV infusion or Subcut

Dosage Ranges

Clinical / research use (neurology, addiction, anti-aging trials):

100mg-250mg mg IV per session, slow infusion

Wellness IV practice:

• Low dose (introductory): 100–250 mg IV (1–2.5 mL) (recommended to start)
• Standard dose: 250–500 mg IV (2.5–5 mL, up to one vial)
• High dose (specialised protocols): 750–1000 mg IV, split across multiple vials/sessions (NOT Recommended)

Dilution & infusion:

• Dilute into 250–500 mL 0.9% NaCl or Hartmann's
• Infusion time:
• 100–250 mg: over 1–2 hours
• 500 mg: usually 2–4 hours
• 750–1000 mg: may take 4–6 hours (split bag or very slow rate)
• Always titrate drip rate to tolerance (many clients feel chest tightness, nausea, anxiety, or flushing if infused too quickly).
• If you find that your client feels unwell with IV, Subcutaneous is another way to administer

Frequency:

• Wellness/anti-aging: weekly to monthly
• Intensive protocols (addiction, recovery): daily or every second day for 4–10 days (specialist use only)

Clinical / Wellness Benefits

• Mitochondrial function: restores ATP production
• Cellular repair: supports DNA repair enzymes (sirtuins, PARPs)
• Healthy-aging & longevity: improves energy, cognition, resilience
• Neurological health: may support mood, focus, memory, addiction recovery
• Metabolic health: improves insulin sensitivity, supports fat metabolism
• Synergy: often stacked with CoQ10, Glutathione, B Complex, Vitamin C

Safety & Precautions

• Most important factor = infusion rate
• Too rapid → flushing, chest pressure, abdominal cramping, nausea, anxiety
• Always slow down if symptoms occur
• Well tolerated at appropriate rates/doses
• No known serious long-term adverse effects at wellness doses
• Avoid in pregnancy, breastfeeding, severe liver/renal disease unless medically indicated
• Consider baseline labs if frequent use (CBC, LFTs, renal, glucose, NAD metabolite markers if available)

Australian Injectable Drugs Handbook

Nicotinamide Adenine Dinucleotide (NAD+)

No data on NAD+ on AIDH