GAMMA AMINOBUTYRIC ACID

MEDICATION DETAILS

Drug: Gamma-Aminobutyric Acid (GABA)

Form: Injectable solution

Concentration: 25 mg/mL

Vial: 10 mL multidose vial

Total content: 250 mg

Gamma-Aminobutyric Acid (GABA) WELLNESS DOSE

IM Dose - 0.5-1ML - 12.5-25mg

Injection technique

• Site: Gluteal or deltoid
• Rate: Slow IM over 30–60 seconds
• Frequency - once a week

IV Dose - 0.5-1ml = 12.5-25mg

Total - Do NOT administer more than the wellness dose indicated.

Administration Requirements

• Dilution: 100–250 mL 0.9% Sodium Chloride
• Method: IV infusion ONLY
• Rate: Infuse over 30–60 minutes minimum
• Monitoring: Continuous BP, HR, symptom observation

IV Use is PROHIBITED if:

• Dose exceeds 25 mg
• IV push or bolus is attempted
• Patient is on sedatives, opioids, alcohol
• Monitoring or resuscitation capacity is unavailable

EXPECTED EFFECTS

• Onset: 10–30 minutes
• Peak: 30–90 minutes
• Duration: 2–6 hours

Common effects

• Calm, relaxed state
• Reduced anxiety or mental hyperarousal
• Mild sedation (dose-dependent)

CONTRAINDICATIONS & CAUTIONS

Absolute Contraindications

• Known hypersensitivity to GABA
• Pregnancy or breastfeeding
• Acute intoxication (alcohol, sedatives, opioids)

Relative Contraindications / Use With Caution

• Concurrent benzodiazepines, opioids, hypnotics
• Hypotension or autonomic instability
• Severe respiratory disease
• History of paradoxical reactions to calming agents

ADVERSE EFFECTS & MANAGEMENT

Common (usually mild)

• Drowsiness
• Injection site discomfort
• Light-headedness

INDICATIONS FOR WELLNESS USE

Injectable GABA may be used as adjunctive support for:

• Acute stress or anxiety states
• Sympathetic nervous system over-activation
• Sleep initiation difficulty
• Nervous system dysregulation
• Menopausal autonomic symptoms
• Burnout / fatigue with heightened arousal

OBSERVATION & AFTERCARE

• Observe patient 15–30 minutes post-administration
• Advise:
• No driving or operating machinery for several hours if sedated
• Avoid alcohol or sedatives same day