EDETATE CALCIUM DISODIUM (CaNa₂EDTA)
DOSING & ADMINISTRATION (Has been Doctor-Determined)
STANDARD ADULT DOSE (Medical Lead Chelation Range)
- 1000–3000 mg/day (50–75 mg/kg/day), per doctor order
- Maximum: 75 mg/kg/day
- Dose must be calculated to patient weight & renal function
IV INFUSION INSTRUCTIONS
Dilute dose in 250–500 mL of:
- 0.9% Sodium Chloride or D5W
- Infuse via pump over 1–3 hours (slower in sensitive patients)
- Monitor renal markers closely for multi-day protocols
INFUSION FREQUENCY
Depends on clinical indication:
- Acute toxicity: Daily for up to 5 days
- Chronic toxicity/integrative care: 1–2× weekly as medically directed
MAXIMUM INFUSION RATE
Not faster than 15 mg/kg/hour
CLINICAL INDICATIONS
Doctor assessment is mandatory. CaNa₂EDTA is typically used for:
Validated Indications
- Acute or chronic lead poisoning (serum lead above reference or symptomatic)
- Cadmium toxicity
- Supportive chelation where other metals are implicated, per doctor assessment
Wellness/Integrative Context (Must Avoid Therapeutic Claims Under TGA)
You may describe it as:
"Used in integrative medical settings under medical supervision for the removal of certain heavy metals."
Do not advertise it for:
- Cardiovascular disease reversal
- Anti-aging
- Autism
- Any disease claims (TGA prohibited)
CONTRAINDICATIONS
- Anuria or severe renal impairment
- Active hepatitis or significant hepatic dysfunction
- Pregnancy or breastfeeding
- Hypersensitivity to EDTA
- Hypocalcemia (although calcium disodium EDTA is safer than disodium EDTA, caution still applies)
PRE-TREATMENT REQUIREMENTS
Baseline Testing (Mandatory)
- CMP/U&Es (renal panel)
- LFTs
- CBC
- Serum electrolytes
- Urinalysis
- Heavy metals panel if indicated by the doctor
Validated Indications
- Acute or chronic lead poisoning (serum lead above reference or symptomatic)
- Cadmium toxicity
- Supportive chelation where other metals are implicated, per doctor assessment
POST-TREATMENT CARE
- Encourage additional hydration (oral + IV if required)
- Avoid strenuous activity for 24 hours
- Post-chelation supplementation (doctor-directed):
- Zinc
- Magnesium
- Trace minerals
- Antioxidants (Vitamin C, glutathione, NAC – where appropriate)
Monitoring
- Re-test renal function every 3–5 infusions
- Heavy metals re-testing every 6–12 weeks if under ongoing chelation program
ADVERSE EFFECTS
Common
- Fatigue
- Metallic taste
- Headache
- Irritation at infusion site
- Hypotension (rapid infusion)
Serious (Rare)
- Nephrotoxicity
- Hypocalcemia
- Arrhythmias
- Liver enzyme elevation
- Anuria/severe renal failure (stop immediately)
Stop infusion immediately and escalate per emergency protocol.
EMERGENCY MANAGEMENT
Signs of reaction
- Chest tightness
- Severe headache
- Tachycardia
- Hypotension
- Urticaria
- Reduced urine output
Actions
- Stop infusion
- Keep IV cannula in situ
- Vital signs q2–5 min
- Apply oxygen if required
- Contact supervising doctor
- Activate emergency plan / ambulance if deterioration
- Document incident fully
SAFETY & COMPLIANCE POLICY
Clinical Governance
- Chelation therapy MUST be ordered by the clinic's prescribing doctor
- Clear pathway required for medical review before and after treatment
- Protocols must align with TGA, AHPRA & NSW Poisons standards
Scope of Practice
- Nurses and paramedics may administer under medical direction
- Must NOT advertise as treatment for unapproved indications
- Must NOT claim detox, cure, disease treatment, or guaranteed outcomes
Documentation
- Doctor script
- Batch number & vial tracing
- Consent form
- Pre-assessment checklist
- Infusion chart
- Post-care notes
Storage
- Store at 15–25°C
- Protect from light
- Single-use vial (discard unused portion)