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# B COMPLEX (B1/B2/B3/B5)

B Complex (IV formulation) typically contains:

- Vitamin B1 (Thiamine hydrochloride)
- Vitamin B2 (Riboflavin sodium phosphate)
- Vitamin B3 (Nicotinamide)
- Vitamin B5 (Dexpanthenol / Calcium pantothenate)

Always doctor-prescribed and pharmacy-compounded.

## General Wellness Dosing

- **Thiamine (B1):** 25–100 mg IV
- **Riboflavin (B2):** 2–10 mg IV
- **Nicotinamide (B3):** 25–100 mg IV
- **Dexpanthenol (B5):** 250–500 mg IV

## Clinical Benefits

- Energy metabolism: supports ATP production
- Nervous system: helps reduce fatigue, stress support
- Liver detox pathways (methylation, phase I/II enzymes)
- Hair, skin, nails health
- Mood & cognition support (especially B6, B3)

## Safety Notes

- Preferred route is IM
- Always dilute in 500ml Hartmanns carrier fluid; direct IV push can cause vein irritation.
- Thiamine (B1): rare anaphylaxis has been reported; infuse slowly.
- Nicotinamide (B3) may cause warmth/flush sensation if given too fast.
- Safe for most people, but caution in severe renal impairment or liver disease.
- Always obtain baseline bloods if doing regular therapy (folate, liver function, kidney function).

## Summary Protocol:

- Add 1–2 ampoules (≈2–4 mL) B Complex to 250–500 mL IV fluids
- Infuse slowly over 30–60 min
- **Frequency:** weekly to fortnightly depending on needs
- Must be doctor-prescribed, pharmacy-compounded, and TGA-compliant

## Common & Mild Adverse Reactions

Often rate-related and transient:

- Warmth / flushing
- Nausea
- Metallic or bitter taste
- Headache
- Lightheadedness
- Mild diaphoresis
- Urine bright yellow (riboflavin – harmless)

## Australian Injectable Drugs Handbook

https://aidh.hcn.com.au/browse/v/vitamins_b_group

### STABILITY

B-Dose Forte: store at 2 to 8 °C. Do not freeze. Protect from light.1

B-Dose and IV B-Dose: store below 25 °C. Protect from light.1

### INCOMPATIBILITY

No information

### REFERENCES

1. Product information. Available from www.tga.gov.au. Accessed 29/08/2022.
2. Kerr S. pH of injectable products [email]. Braeside, Victoria: Biological Therapies; 04/11/2022.
3. Water-soluble vitamin deficiencies [August 2022]. In: Therapeutic Guidelines [internet]. Melbourne: Therapeutic Guidelines Limited; August 2022.

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