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# GAMMA AMINOBUTYRIC ACID

## MEDICATION DETAILS

**Drug:** Gamma-Aminobutyric Acid (GABA)

**Form:** Injectable solution

**Concentration:** 25 mg/mL

**Vial:** 10 mL multidose vial

**Total content:** 250 mg

## Gamma-Aminobutyric Acid (GABA) WELLNESS DOSE

### IM Dose - 0.5-1ML - 12.5-25mg

**Injection technique**

- **Site:** Gluteal or deltoid
- **Rate:** Slow IM over 30–60 seconds
- **Frequency** - once a week

### IV Dose - 0.5-1ml = 12.5-25mg

**Total** - Do NOT administer more than the wellness dose indicated.

### Administration Requirements

- **Dilution:** 100–250 mL 0.9% Sodium Chloride
- **Method:** IV infusion ONLY
- **Rate:** Infuse over 30–60 minutes minimum
- **Monitoring:** Continuous BP, HR, symptom observation

### IV Use is PROHIBITED if:

- Dose exceeds 25 mg
- IV push or bolus is attempted
- Patient is on sedatives, opioids, alcohol
- Monitoring or resuscitation capacity is unavailable

## EXPECTED EFFECTS

- **Onset:** 10–30 minutes
- **Peak:** 30–90 minutes
- **Duration:** 2–6 hours

### Common effects

- Calm, relaxed state
- Reduced anxiety or mental hyperarousal
- Mild sedation (dose-dependent)

## CONTRAINDICATIONS & CAUTIONS

### Absolute Contraindications

- Known hypersensitivity to GABA
- Pregnancy or breastfeeding
- Acute intoxication (alcohol, sedatives, opioids)

### Relative Contraindications / Use With Caution

- Concurrent benzodiazepines, opioids, hypnotics
- Hypotension or autonomic instability
- Severe respiratory disease
- History of paradoxical reactions to calming agents

## ADVERSE EFFECTS & MANAGEMENT

### Common (usually mild)

- Drowsiness
- Injection site discomfort
- Light-headedness

## INDICATIONS FOR WELLNESS USE

Injectable GABA may be used as adjunctive support for:

- Acute stress or anxiety states
- Sympathetic nervous system over-activation
- Sleep initiation difficulty
- Nervous system dysregulation
- Menopausal autonomic symptoms
- Burnout / fatigue with heightened arousal

## OBSERVATION & AFTERCARE

- Observe patient 15–30 minutes post-administration
- **Advise:**
- No driving or operating machinery for several hours if sedated
- Avoid alcohol or sedatives same day

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