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# NAD+ 500mg & 1000mg

NAD+ is potent and rate-dependent — all administrations must be doctor-prescribed, pharmacy-compounded, and clinician-administered under strict governance and TGA compliance.

## Product Information

**Drug:** Nicotinamide Adenine Dinucleotide (oxidised form)

**Concentration:** 100 mg/mL

**Vial size:** 5 mL (total = 500 mg NAD+ or 10ml - 1000mg NAD+)

**Route:** IV infusion or Subcut

## Dosage Ranges

### Clinical / research use (neurology, addiction, anti-aging trials):

100mg-250mg mg IV per session, slow infusion

### Wellness IV practice:

- **Low dose (introductory):** 100–250 mg IV (1–2.5 mL) (recommended to start)
- **Standard dose:** 250–500 mg IV (2.5–5 mL, up to one vial)
- **High dose (specialised protocols):** 750–1000 mg IV, split across multiple vials/sessions (NOT Recommended)

### Dilution & infusion:

- Dilute into 250–500 mL 0.9% NaCl or Hartmann's
- **Infusion time:**
- 100–250 mg: over 1–2 hours
- 500 mg: usually 2–4 hours
- 750–1000 mg: may take 4–6 hours (split bag or very slow rate)
- Always titrate drip rate to tolerance (many clients feel chest tightness, nausea, anxiety, or flushing if infused too quickly).
- If you find that your client feels unwell with IV, Subcutaneous is another way to administer

### Frequency:

- **Wellness/anti-aging:** weekly to monthly
- **Intensive protocols (addiction, recovery):** daily or every second day for 4–10 days (specialist use only)

## Clinical / Wellness Benefits

- Mitochondrial function: restores ATP production
- Cellular repair: supports DNA repair enzymes (sirtuins, PARPs)
- Healthy-aging & longevity: improves energy, cognition, resilience
- Neurological health: may support mood, focus, memory, addiction recovery
- Metabolic health: improves insulin sensitivity, supports fat metabolism
- Synergy: often stacked with CoQ10, Glutathione, B Complex, Vitamin C

## Safety & Precautions

- **Most important factor = infusion rate**
- Too rapid → flushing, chest pressure, abdominal cramping, nausea, anxiety
- Always slow down if symptoms occur
- Well tolerated at appropriate rates/doses
- No known serious long-term adverse effects at wellness doses
- Avoid in pregnancy, breastfeeding, severe liver/renal disease unless medically indicated
- Consider baseline labs if frequent use (CBC, LFTs, renal, glucose, NAD metabolite markers if available)

## Australian Injectable Drugs Handbook

Nicotinamide Adenine Dinucleotide (NAD+)

No data on NAD+ on AIDH

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